WS 75624 A and B , New Endothelin Converting Enzyme Inhibitors
نویسندگان
چکیده
mental analysis1} and high resolution fast atom bombardment MS (HRFAB-MS)1* and 13C NMRspectral data (Table 1). All 18 carbon signals were seen in the 13G NMRspectrum, consisting of one methyl, 5 CH2, 2 methoxy, one oxymethine, 2 =CH and 7 sp2 quaternary carbons. These groups accounted 22 non-exchangeable protons and therefore 2A possesses 2 exchangeable protons. It reacted quickly with trimethylsilyldiazo-
منابع مشابه
Biological and pharmacological properties of highly selective new endothelin converting enzyme inhibitor WS79089B isolated from Streptosporangium roseum No. 79089.
WS79089B a highly specific endothelin converting enzyme (ECE) inhibitor has been isolated from the fermentation broth of Streptosporangium roseum No. 79089. WS79089B showed highly selective ECE inhibition activity with IC50 value of 0.14 microM and behaved as a competitive inhibitor of ECE, with Ki values of 8.9 x 10(-8) M. The sodium salt of WS79089B (FR901533) inhibited big endothelin-1 (big ...
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